mSAS® Compatibility

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Prevista AI™ has processed your compound and determined an overall mSAS® compatibility of

 Your compound would be highly compatible with our mSAS® technology. From this initial evaluation it is clear that the processing risk is negligible and we would be delighted to work with you on a project. If you would like to discuss further, please email Steven Nicholson at steven.nicholson@crystecpharma.com. We look forward to hearing from you soon.

Although there are some small processing risks your compound remains a good fit for processing using our mSAS® technology and we would be delighted to perform a feasibility study on your compound. If you would like to discuss further, please email Steven Nicholson at steven.nicholson@crystecpharma.com. We look forward to hearing from you soon

Although there is increased risk of processing your compound with our mSAS® technology there are usually ways to overcome these challenges. These risks can usually be mitigated on a compound-to-compound basis so feel free to contact us regarding a feasibility study. If you would like to discuss further, please email Steven Nicholson at steven.nicholson@crystecpharma.com. We look forward to hearing from you soon.

Your compound requires specific risk mitigation due to unfavourable thermodynamic properties/hydrocarbon solubility/molecular structure/solubility in organic solvents. Although there is increased risk of processing your compound with our mSAS® technology there may be ways to overcome these challenges and these risks can be mitigated on a compound-to-compound basis. If you would like to discuss further, please email Steven Nicholson at steven.nicholson@crystecpharma.com. We look forward to hearing from you soon.

Full Report

Hydrocarbon Solubility
Hydrocarbon Solubility
Compatibility Level Solubility Range (mg/ml) Description
High Compatibility 1 Solubility in hydrocarbons gives us a good idea of how soluble your compound will be in CO2. Your compound has a low solubility in hydrocarbon solvents meaning that there is a good chance of achieving high throughput and identifying a broad range of particle engineering options for your compound when processing with mSAS®.
Moderate Compatibility 1-5 Solubility in hydrocarbons gives us a good idea of how soluble your compound will be in CO2. Your compound has a moderate solubility in hydrocarbon solvents which may reduce the throughput of your compound in the mSAS® process and reduce particle engineering opportunities. We can perform a feasibility study to see if your compound is soluble in CO2 by performing a gravimetric screen in our kit. It is possible to introduce a modifier into our supercritical CO2 stream which enhances the anti-solvent capability of CO2 to provide additional processing opportunities.
Low Compatibility 5 Solubility in hydrocarbons gives us a good idea of how soluble your compound will be in CO2. Your compound has a high solubility in hydrocarbon solvents which is likely to affect the throughput of your compound in the mSAS® process and reduce particle engineering opportunities. It is possible to introduce a modifier into our supercritical CO2 stream which enhances the anti-solvent capability of CO2 to provide additional processing opportunities.
Thermodynamic Properties
Thermodynamic Properties
Compatibility Level Temperature Range (°C) Description
High Compatibility 150 The thermodynamic properties of your compound are highly compatible with mSAS®. This means there is an increased experimental space that we can work in which increases the chance of project success.
Moderate Compatibility 70-150 The thermodynamic properties of your compound are broadly compatible with mSAS®. The experimental space we can work in is slightly decreased and there is a small chance of an ‘oiling out’ phenomenon occurring. However, it is still highly likely that we will be able to produce powder with your compound. We can work with you to perform a feasibility study on your compound to understand where in experimental space powder can be formed using mSAS®.
Low Compatibility <70 The thermodynamic properties of your compound are somewhat unfavourable for processing using mSAS®. The experimental space we can work in is decreased and there is a chance of an ‘oiling out’ phenomenon occurring. However, it may still be likely that we will be able to form powder with your compound. We can work with you to perform a feasibility study to understand if powder can be formed using mSAS®.
Molecular Structure
Molecular Structure
Compatibility Level Structure Range Description
High Compatibility 0 Your compound has a molecular structure which indicates that it may have low solubility in CO2. This means there is a good chance of achieving high throughput and identifying a broad range of particle engineering options for your compound when processing with mSAS®.
Moderate Compatibility 1-7 Your compound has a molecular structure which indicates that it may have solubility in CO2. This may affect the throughput and of your compound when processing using mSAS®. We can perform a feasibility study to see if your compound is soluble in CO2 by performing a gravimetric screen in our kit.
Low Compatibility >7 Your compound has a molecular structure which indicates that it may have solubility in CO2. This may affect the throughput in the mSAS® process and reduce particle engineering opportunities. We can generate a composite particle or form a cocrystal of your compound if viable or reduce the amount of supercritical CO2 used for certain projects to mitigate this.
Solubility Number
Solubility Number
Compatibility Level Solubility Range Description
High Compatibility >3 Your compound is soluble in a number of different organic solvents. This increases the experimental space that we can work in and the overall chance of success with the project.
Moderate Compatibility 2/3 Your compound is soluble in a few different organic solvents. The experimental space we can work in will be decreased but we can perform a kinetic solubility study on your compound to see if there are any other viable solvents or solvent mixtures that we can work with.
Low Compatibility <2 Your compound has low solubility in organic solvents. The experimental space we can work in will be decreased but we can perform a kinetic solubility study on your compound to see if there are any other viable solvents or solvent mixtures that we can work with.
Solubility Concentration
Solubility Concentration
Compatibility Level Solubility Range Description
High Compatibility >50 Your compound has high solubility which not only increases the experimental space which we can work with but also increases the throughput when processing through mSAS®.
Moderate Compatibility 5-50 Your compound has moderate solubility in the listed solvents which may have a minor effect on the throughput of your compound when processing using mSAS®. We will test a number of solvents and solvent systems to determine which solvents and solvent mixtures would increase the throughput.
Low Compatibility <5 Your compound has low solubility in the listed solvents which can have an effect on the throughput of your compound through mSAS®. We will test a number of solvents and solvent systems to determine which solvents and solvent mixtures would increase the throughput.

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